FOXO4 10mg
FOXO4-DRI senolytic peptide designed to selectively target senescent cells by disrupting the FOXO4/p53 interaction.
What is FOXO4?
FOXO4 (FOXO4-DRI) is a D-amino acid retro-inverso peptide designed to selectively target and eliminate senescent cells — aged, dysfunctional cells that accumulate with age and drive chronic inflammation and tissue dysfunction. It is one of the most targeted senolytic compounds available for research, acting through a specific protein-protein interaction rather than broad cytotoxicity.
Key Features
- Highly targeted senolytic — selectively eliminates senescent cells
- D-amino acid retro-inverso design for enhanced stability
- Disrupts FOXO4/p53 interaction without broad cytotoxicity
- High purity ≥98% verified by RP-HPLC and mass spectrometry
Mechanism of Action
Senescent cells survive by upregulating FOXO4, which interacts with p53 to suppress apoptosis (programmed cell death). FOXO4-DRI disrupts this FOXO4/p53 interaction, restoring p53's ability to trigger apoptosis specifically in senescent cells. Because non-senescent cells do not rely on this FOXO4/p53 survival mechanism, FOXO4-DRI selectively eliminates senescent cells while leaving healthy cells intact. This targeted senolysis reduces the senescence-associated secretory phenotype (SASP) — the pro-inflammatory cytokine release that drives inflammaging.
Research Applications
- Cellular senescence and senolytic research
- Healthspan and longevity pathway investigation
- FOXO4/p53 protein-protein interaction studies
- Senescence-associated secretory phenotype (SASP) research
- Age-related tissue dysfunction and regeneration models
- Inflammaging and chronic inflammation research
Reconstitution Guide
Reconstitute with sterile bacteriostatic water or DMSO (for poorly soluble batches). Add solvent slowly. Gently swirl — do not shake. Store reconstituted solution at 2–8°C and use within 14 days.
Research Use Only. For research use only. Not for human or veterinary use. Not for sale to the general public. All products are intended solely for in vitro research and laboratory use. Helix Biotech does not endorse, encourage, or condone the use of any research compounds in humans or animals.
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