Humanin 10mg
Mitochondria-encoded peptide researched for cellular protection, energy metabolism, neuroprotection, and healthy ageing.
What is HMN10?
Humanin is a naturally occurring peptide encoded within the mitochondrial genome — specifically within the 16S ribosomal RNA gene. It was first identified through its ability to suppress neuronal cell death associated with Alzheimer's disease. As a mitochondria-derived peptide (MDP), Humanin represents a new class of signalling molecules that communicate cellular stress states and regulate survival pathways across tissues.
Key Features
- Endogenous mitochondria-encoded peptide with broad cytoprotective activity
- Neuroprotective via suppression of amyloid-beta and BAX-mediated apoptosis
- Activates JAK2/STAT3 and AMPK survival signalling pathways
- High purity ≥98% verified by RP-HPLC and mass spectrometry
Mechanism of Action
Humanin exerts its effects through multiple receptor-mediated pathways. It binds to the tripartite receptor complex comprising CNTFR, WSX-1, and gp130, activating JAK2/STAT3 signalling to promote cell survival. It also interacts with IGFBP-3 and BAX to inhibit apoptosis. In metabolic contexts, Humanin activates AMPK and improves insulin sensitivity. Its neuroprotective effects are linked to suppression of amyloid-beta toxicity and mitochondrial membrane stabilisation.
Research Applications
- Mitochondrial function and bioenergetics research
- Neuroprotection and Alzheimer's disease pathway studies
- Cellular senescence and healthy ageing investigation
- Cardiovascular protection and vascular health research
- Insulin sensitivity and metabolic health studies
- Apoptosis regulation and cell survival pathway research
Reconstitution Guide
Reconstitute with sterile bacteriostatic water. Add solvent slowly down the side of the vial. Gently swirl — do not shake. Store reconstituted solution at 2–8°C and use within 28 days.
Research Use Only. For research use only. Not for human or veterinary use. Not for sale to the general public. All products are intended solely for in vitro research and laboratory use. Helix Biotech does not endorse, encourage, or condone the use of any research compounds in humans or animals.
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