CJC-1295 with DAC 5mg
GHRH analogue with Drug Affinity Complex modification for extended half-life research.
What is CJC1295?
CJC-1295 with DAC (Drug Affinity Complex) is a synthetic analogue of GHRH(1-29) modified with a lysine linker and maleimidoproprionic acid (MPA) group that enables covalent binding to serum albumin. This modification dramatically extends the half-life compared to native GHRH, making it a valuable tool for studying sustained GH axis stimulation.
Key Features
- Extended half-life via albumin-binding DAC technology
- Full GHRH receptor agonist activity
- Ideal for sustained GH release studies
- High purity ≥98% verified by mass spectrometry
Mechanism of Action
The DAC modification allows CJC-1295 to bind covalently to circulating albumin via a Michael addition reaction, protecting it from enzymatic degradation. This results in a prolonged half-life of approximately 6–8 days compared to minutes for native GHRH. The compound retains full GHRH receptor agonist activity, stimulating pulsatile GH release from pituitary somatotrophs.
Research Applications
- Long-acting GHRH receptor agonism studies
- Sustained GH axis stimulation research
- Albumin-binding drug delivery mechanism studies
- GH/IGF-1 axis pharmacokinetics
- Comparative GHRH analogue studies
Reconstitution Guide
Reconstitute with sterile bacteriostatic water. Store at 2–8°C after reconstitution and use within 28 days.
Research Use Only. For research use only. Not for human or veterinary use. All products are intended solely for in vitro research and laboratory use. Helix Biotech does not endorse, encourage, or condone the use of any research compounds in humans or animals.
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